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● Live R strain in the presence of heatkilled S strain produce virulence
because somehow R strain bacteria is transformed by heatkilled S
strain bacteria. Hence, it was concluded that there must be transfer of
genetic material.
Biochemical Nature of Transforming Material
● Avery, McLeod, and McCarthy worked to determine the biochemical
nature of genetic material responsible for transformation.
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● This suggests that DNA has to be the genetic material.
Hershey and Chase Experiment to Confirm DNA as the Genetic
Material