Page 1 - Microsoft Word - Lesson note-1(Amines)

SUBJECT-CHEMISTRY

CHAPTER-AMINES.

 Form nitrocompounds

Sn/HCl
C H NO  g[H ] C H NH  H O
2 5
2
2 5
2
2
Sn/HCl
C H NO  g[H] C H NH  H O
6 5
2
6 5
2
2
Fe/HCl

 Ammonolysis of alkyl halides
 
Rx
Rx
Rx

R NH  R NH R N R N X
4
3
2
2
1 o 2 o 3 o 4 o
 

R NH X  NaOH  R NH  H O NaX


2
3
2
 Reduction of nitriles
2 H /Ni
R C N  R CH  NH



Na(Hg)/C 2 5 H OH 2 2
 Reduction of amides.
O
||
(i)LiAIH


R C NH  R CH  NH

4
2
2
2
Na(Hg)/C
2 5 H OH
 Gabriel-phthalimide synthesis:

 Hoffmann broide degradation reaction:

Chemical character
 Basic character


(CH ) NH CH NH  (CH ) N NH
3 3
3
3 2
2
3
2 o 1 o 3 o
 alkylation
 
RX
RX
RX

R NH  R NH  R N  R N X
3
2
4
2
 acylation
CH
C H NH  CH COCl  C H NHCO CH  HCl
3
2 5
2
2 5
3
3
H
|| 
OH


C H N  CH C Cl C H  N  C CH  HCl
2 5
|| 3 || 2 5 || || 3
C 2 5 H O C 2 5 H O

 carbylamines reaction: